Ahli Gizi Online

Oxygen, hypoxia, oxygen tension in human obesity

Posted on: 22 November 2012

Freitag's Nutrition

A new review published from current opinion clinical nutrition and metabolism. And this is worth attention.

There is a growing number of studies investigating on the role of oxygen in development of obesity. In obese mice, its been reported that there are changes in morphology of mithocondria, reduction on mitochondrial biogenesis and mass and more importantly, lower oxygen consumption of the cell. This oxygen consumtion (pergram) also seen in obese individual. Before more talk about more about oxygen, i would like to describe some term in this field.

Adipose tissue oxygen tension or PO2 is the result of balance between adipose tissue blood flow (ATBF) and metabolic rate. Decreased ATBF might affect lipid buffering capacity of adipocyte. That would lead to reduction of clearence of circulating TG and increase re-esterification of FA.

Other from ATBF, oxygen consumption should also be considered as important factor. In obese subjects, there is a…

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