Anti-hypoxia works as anti-obesity… New obesity treatment is found
Posted 22 November 2012on:
It is just recently published in PlosOne journal that Shin et al. successfully reduce body weight of diet induced obesity using HIF-1 alpha antisense oligonucleotide or ASO. HIF-1 alpha or hypoxia inducible factor-1 is protein that expressed when oxygen in the cell or tissue are low. This protein is sensitive to oxigen level in human body.
Hypoxia in obesity is a new research field with a lot of potentials. These studies were started when scientists found the fact that hypoxia occured in adipose tissues of obese humans and animal model. Earlier this year, a research group from United Kingdom shown a promising result from their microarray analysis that hypoxia in adipocyte induced changes in lipolysis and fat oxidation pathway. Mice model has also been used in the other studies showing that knock out HIF-1 alpha is able to protect against obesity while constitutive activation could lead to mild obesity.
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