Ahli Gizi Online

Anti-hypoxia works as anti-obesity… New obesity treatment is found

Posted on: 22 November 2012

Freitag's Nutrition

It is just recently published in PlosOne journal that Shin et al. successfully reduce body weight of diet induced obesity using HIF-1 alpha antisense oligonucleotide or ASO. HIF-1 alpha or hypoxia inducible factor-1 is protein that expressed when oxygen in the cell or tissue are low. This protein is sensitive to oxigen level in human body.

Hypoxia in obesity is a new research field with a lot of potentials. These studies were started when scientists found the fact that hypoxia occured in adipose tissues of obese humans and animal model. Earlier this year, a research group from United Kingdom shown a promising result from their microarray analysis that hypoxia in adipocyte induced changes in lipolysis and fat oxidation pathway. Mice model has also been used in the other studies showing that knock out HIF-1 alpha is able to protect against obesity while constitutive activation could lead to mild obesity.


Lihat pos aslinya 249 kata lagi

Tinggalkan Balasan

Isikan data di bawah atau klik salah satu ikon untuk log in:

Logo WordPress.com

You are commenting using your WordPress.com account. Logout / Ubah )

Gambar Twitter

You are commenting using your Twitter account. Logout / Ubah )

Foto Facebook

You are commenting using your Facebook account. Logout / Ubah )

Foto Google+

You are commenting using your Google+ account. Logout / Ubah )

Connecting to %s

Blog Stats

  • 111,458 hits

Enter your email address to follow this blog and receive notifications of new posts by email.

Bergabunglah dengan 498 pengikut lainnya

November 2012
« Okt   Des »

Komentar Terbaru

hrd di Lowongan Nutritionist WRP Diet…
Andi Musdalifa Tenri… di Lowongan Nutritionist Euromedi…
%d blogger menyukai ini: